Automated Blood Processing Systems for Regenerative & Diagnostic Applications
At 2M Engineering, we develop automated sample preparation and microfluidic systems that transform complex biological processing into reliable, reproducible and user-friendly workflows.
Our expertise spans sensor-controlled centrifugation, intelligent fluid handling, microfluidic separation principles and medical device engineering, enabling high-quality sample preparation for regenerative medicine, diagnostics and future point-of-care applications.
From Manual Handling to Intelligent Sample Processing
Sample preparation is often the weakest link in medical workflows:
- highly operator-dependent
- time-consuming
- difficult to standardize
- sensitive to contamination and variability
2M Engineering addresses this challenge by designing fully automated, sensor-driven systems that ensure consistent output quality, minimal user interaction and regulatory readiness.
Case Study: Fully Automated PRP Separation System (ANGELINA)
ANGELINA is a fully automated Platelet-Rich Plasma (PRP) separation system, developed by 2M Engineering as a functional prototype to explore next-generation approaches in blood processing.
Unlike conventional PRP systems, ANGELINA performs the entire separation process in one continuous, closed workflow, without manual transfers or intermediate handling steps.
This project serves as a technology demonstrator for advanced sample preparation, microfluidic control and sensor-driven decision making in medical devices.
Intelligent, Sensor-Controlled Blood Separation
ANGELINA integrates multiple sensing principles to control and optimize the separation process in real time:
- patented sensor technology for platelet concentration monitoring
- optical sensing to detect phase boundaries between blood constituents
- real-time camera-assisted process verification
- intelligent procedure-selection algorithms based on medical workflows
By combining sensing, control and automation, the system delivers highly consistent and extremely clean PRP, independent of operator experience.
Key Characteristics of the ANGELINA System
- fully automated tabletop PRP centrifuge
- closed, disposable-based processing workflow
- no manual blood transfer during processing
- total processing time < 20 minutes
- capacity up to 500 ml whole blood
- affordable, easy-to-replace disposable kit
- real-time visual and sensor-based process control
- reproducible, high-purity PRP output
Designed for Regenerative Medicine Workflows
The ANGELINA concept supports a wide range of regenerative and surgical applications, including:
- chronic wound care
- tendon and ligament injuries
- bone growth stimulation
- surgical wound healing
- cosmetic and reconstructive procedures
- fat transplantation and collagen stimulation
By standardizing PRP quality and reducing handling complexity, such systems lower the threshold for broader clinical adoption.
Beyond PRP: A Platform for Advanced Sample Preparation
The technologies explored in ANGELINA extend far beyond PRP processing.
With targeted modifications, the same architecture can support:
- stem cell isolation from fat tissue or bone marrow
- automated preparation of cellular therapies
- microfluidic enrichment of specific blood fractions
- future point-of-care diagnostic sample preparation
This makes ANGELINA a platform concept rather than a single product.
2M Engineering’s Role & Expertise
Within this project, 2M Engineering was responsible for:
- system architecture and workflow design
- sensor integration and control algorithms
- mechanical and mechatronic engineering
- disposable design strategy
- usability and clinical workflow alignment
- preparation for medical device certification pathways
This reflects our broader capability to translate complex biological processes into regulated, manufacturable medical systems.
Sample Preparation as an Enabler for Diagnostics & Therapy
Reliable sample preparation is essential for:
- regenerative medicine
- cell-based therapies
- biomarker diagnostics
- point-of-care testing
- automated laboratory workflows
At 2M Engineering, we treat sample preparation as a core enabling technology, tightly integrated with sensing, control and system intelligence.
Looking for a Partner in Sample Preparation & Microfluidics?
If you are developing:
- automated blood or bio-sample processing systems
- microfluidic separation technologies
- regenerative medicine devices
- point-of-care diagnostic workflows
2M Engineering can support you from concept and feasibility through to certification-ready product development.