Simple & fast sample preparation for LTA platelet function testing
In the Thrombospin project we created a first prototype of a full automatic LTA sample preparation device that replaces all the time consuming manual work. LTA (Light Transmission Aggregometry) is the (golden) standard blood test to diagnose platelet function. Today the manual sample preparation steps take a lot of expert time and hassle. The aim of the Thrombospin project is to take out all this hassle.
Platelet function testing
Platelet aggregation testing measures the ability of various agonists to platelets to induce in vitro activation and platelet-to-platelet activation. Classically Born aggregometry uses platelet rich plasma [PRP]. In the Born aggregometer, PRP is stirred in a cuvette at 37°C and the cuvette sits between a light course and a photocell. When an agonist is added the platelets aggregate and absorb less light and so the transmission increases and this is detected by the photocell. LTA test takes about 30 minutes.
Thrombospin blood sample preparation device
Thrombospin is a controlled table top device with disposable blood separation containers. The system is intended to be used in a clinical setting by qualified professionals for obtaining PRP and PPP from whole blood and counting platelet concentrations in platelet rich plasma (PRP) from a sample of one of this fluid.
Thrombospin enables full automatic platelet extraction for platelet function testing using LTA out of whole blood. The separated platelets are used for platelet function testing via the standard Light Transmission Aggregometry [LTA] method and counted to quantify the obtained platelet concentration, which enhances the accuracy of the LTA measurement.
LTA (Light Transmission Aggregometry) sample preparation process
The following steps are normally taken in doing a LTA test. The aim of the Thrombospin project is to integrate all steps into a single device or simple to use fully automatic tool.
Key features
- Accurate and validated
- Fully automated saving time and money
- Opens possibility for Point of Care platelet function tests
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